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Richard
Richard
Amministratore del forum

[quote1258106390=Richard]
NCBI
PubMed A service of the U.S. National Library of Medicine
and the National Institutes of Health

Bicarbonate increases tumor pH and inhibits spontaneous metastases

Robey IF, Baggett BK, Kirkpatrick ND, Roe DJ, Dosescu J, Sloane BF, Hashim AI, Morse DL, Raghunand N, Gatenby RA, Gillies RJ. Arizona Cancer Center, University of Arizona, Tucson, Arizona, USA.

The external pH of solid tumors is acidic as a consequence of increased metabolism of glucose and poor perfusion. Acid pH has been shown to stimulate tumor cell invasion and metastasis in vitro and in cells before tail vein injection in vivo. The present study investigates whether inhibition of this tumor acidity will reduce the incidence of in vivo metastases. It shows that oral NaHCO(3) selectively increased the pH of tumors and reduced the formation of spontaneous metastases in mouse models of metastatic breast cancer. This treatment regimen was shown to significantly increase the extracellular pH, but not the intracellular pH, of tumors by (31)P magnetic resonance spectroscopy and the export of acid from growing tumors by fluorescence microscopy of tumors grown in window chambers.

NaHCO(3) therapy also reduced the rate of lymph node involvement, yet did not affect the levels of circulating tumor cells, suggesting that reduced organ metastases were not due to increased intravasation. In contrast, NaHCO(3) therapy significantly reduced the formation of hepatic metastases following intrasplenic injection, suggesting that it did inhibit extravasation and colonization. In tail vein injections of alternative cancer models, bicarbonate had mixed results, inhibiting the formation of metastases from PC3M prostate cancer cells, but not those of B16 melanoma.
Although the mechanism of this therapy is not known with certainty, low pH was shown to increase the release of active cathepsin B, an important matrix remodeling protease.
PMID: 19276390 [PubMed – in process]
March 2009
http://www.ncbi.nlm.nih.gov/pubmed/19276390

http://www.curenaturalicancro.com/pdf/bicarbonate-increases-tumor-ph-and-inhibits-metastases.pdf

Abstract
The external pH of solid tumors is acidic as a consequence of
increased metabolism of glucose and poor perfusion. Acid pH
has been shown to stimulate tumor cell invasion and
metastasis in vitro and in cells before tail vein injection
in vivo. The present study investigates whether inhibition of
this tumor acidity will reduce the incidence of in vivo
metastases
. Here, we show that oral NaHCO3 selectively
increased the pH of tumors and reduced the formation of
spontaneous metastases in mouse models of metastatic breast
cancer. This treatment regimen was shown to significantly
increase the extracellular pH, but not the intracellular pH, of
tumors by 31P magnetic resonance spectroscopy and the
export of acid from growing tumors by fluorescence microscopy
of tumors grown in window chambers. NaHCO3 therapy
also reduced the rate of lymph node involvement, yet did not
affect the levels of circulating tumor cells, suggesting that
reduced organ metastases were not due to increased intravasation.
In contrast, NaHCO3 therapy significantly reduced
the formation of hepatic metastases following intrasplenic
injection, suggesting that it did inhibit extravasation and
colonization. In tail vein injections of alternative cancer
models, bicarbonate had mixed results, inhibiting the formation
of metastases from PC3M prostate cancer cells, but not
those of B16 melanoma. Although the mechanism of this
therapy is not known with certainty, low pH was shown to
increase the release of active cathepsin B, an important matrix
remodeling protease. [Cancer Res 2009;69(6):2260–8]
[/quote1258106390]
il punto non è che si neghi totalmente l'efficacia delle terapie convenzionali, ma il dubbio si pone su un abuso di questo tipo di trattamento ed una esclusione forzata di metodi meno tossici, l'obiettivo dovrebbe essere arrivare in collaborazione ad una soluzione che sia a sua volta il meno dannosa possibile..io penso questo in generale
Voglio dire che se la situazione à proprio pesante per l'organismo allora un trattamento piu aggressivo potrebbe anche avere il suo senso..ma non sempre e comunque e addirittura come “prevenzione”, questo personalmente non lo trovo sensato

del resto la medicina fa quanto possibile, ognuno deve prendere coraggio e fare una sua scelta, avendo la possibilità di scegliere chiaramente